Human Chorionic Gonadotropin HCG essentially holds only one valid major use within the anabolic steroid using community, and that is for the purpose of maintaining, increasing, or restoring proper endogenous Testosterone production. HCG doses are best utilized in conjunction with other Testosterone production stimulating compounds during PCT Post Cycle Therapyand the use of HCG alone for the purpose of hormonal recovery after an anabolic steroid cycle is highly advised against.
The practice of using HCG solitarily as the only hormonal recovery agent following the end of a cycle is a bygone practice of the pre era that is obsolete. The understanding of HCG and all other drugs has improved vastly ever since bodybuilders in the s, s, and s have utilized anabolic steroids. In fact, the majority of anabolic steroid users from the s — mid s did not even utilize any compounds for the purpose of hormonal recovery, and the term PCT did not even exist at that time.
When the use of HCG became increasingly popular circait was the only compound utilized. Since then, the medical and scientific understanding of such things has increased exponentially and there should be no reason for any informed and properly educated individual to utilize HCG on its own for PCT. HCG is one compound among the anabolic steroid using community as well as the general public that is highly misunderstood and misused.
The misuse of HCG among the general public as a fat loss agent has already been covered in detail, but it is the misuse among the anabolic steroid using community that is of primary concern here. It is very important to understand some preliminary details and considerations where HCG use is concerned.
First of all, HCG use has demonstrated to increase aromatase activity in the body via increased testicular aromatase expression . Aromatase is the enzyme responsible for the conversion of androgens into Estrogen, and so the result with HCG use is that of an increased level of Estrogen in the body in addition to the Testosterone production stimulation.
Many users have reported developing gynecomastia as a result. Therefore, the use of an aromatase inhibitor is essential during HCG use. The use of HCG, although central to a single purpose, is actually very diverse in the manner by which it can be used, and the protocol of HCG doses, as there are a myriad of different protocols and uses that have been developed over the years.
Only the most effective and prominent protocols will be covered here. Within the medical establishment, HCG is approved for the treatment and recovery of hypogonadism, where prescription protocols refer to several different methods of treatment:. For long-term therapy, a higher dose of 4,IU administered 3 times per week is recommended for a 6 — 9 month period. Following this period, the HCG doses are to then be lowered to 2,IU 3 times per week for a remaining 3 month period.
HCG in particular cannot be categorized into the three tiers of users beginner, intermediate, and advanced as normally outlined and listed in common profiles of the different compounds and drugs. This is due to the fact that HCG is an ancillary drug not particularly used for the purpose of performance enhancement, but instead is utilized to maintain, increase, or restore proper endogenous Testosterone production.
The use of HCG doses during anabolic steroid use must only be performed under very specific conditions and circumstances, and the following must be made pertinently clear to the reader considering HCG use during anabolic steroid cycles:. Unless an individual exhibits very difficult recovery of endogenous Testosterone production following a cycle, there is no need to utilize HCG during anabolic steroid cycles to maintain testicular function.
This is especially true if anabolic steroid cycles are kept short 8 — 10 weeksas testicular atrophy if it does occur will not have remained so for long enough periods of time that there would be difficulty resuming testicular function.
If an individual engages in an anabolic steroid cycle of very long cycle lengths 12 weeks or longerthe use of HCG doses every week during the cycle might be necessary due to the extended time in which testicular atrophy will remain. In excessively long cycles, testicular atrophy can result in greater difficulty in hormonal recovery during PCT as a result of desensitization to gonadotropins.
For the purpose of maintaining testicular function during an anabolic steroid cycle, a standard dose of — IU of HCG doses administered 1 — 2 times weekly each injection spaced evenly apart during the week should be performed if necessary.
It has been clearly stated earlier in this section of the profile that the use of HCG alone is a very bad idea for the purpose of endogenous Testosterone production recovery during PCT. HCG is, for all intents and purposes, synthetic Luteinizing Hormone, and LH just like any other hormone in the human body works on a negative feedback loop whereby when excess exogenous sources of a hormone is detected by the HPTA, the body will suppress or shut down its own endogenous production of the hormone.
It would therefore actually be counterproductive to administer HCG doses alone for hormonal recovery during PCT as many bodybuilders did prior to the s. Although it might have worked for some, the majority of individuals doing this ended up with more endocrine and recovery problems than they had attempted to fix. This is an old outdated practice of the pre bodybuilders and should not be used.
The best possible addition to HCG in a PCT protocol is Nolvadex Tamoxifen Citrateas studies have demonstrated that HCG and Nolvadex utilized together have exhibited a remarkable synergistic effect in terms of stimulating endogenous Testosterone production, and that Nolvadex will actually work to block the desensitization effect on the Leydig cells of the testes caused by high doses of HCG .
Furthermore, it has been outlined early on in this section of this profile that HCG will increase testicular aromatase expression, causing Estrogenic side effects as a result of HCG use. However, the use of HCG with Nolvadex leaves only the most valid choice being Aromasin Exemestaneas studies have demonstrated that when the other two AIs Letrozole or Arimidex are utilized with Nolvadex, Nolvadex will decrease blood plasma concentration of Letrozole as well as Arimidex.
Therefore, the best possible choice of aromatase inhibitor in order to mitigate the increased aromatase activity caused by HCG administration would be Aromasin.Penile growth is under androgenic control. Human chorionic gonadotropin hCG has a stimulatory effect on testicular steroidogenesis and penile growth.
The purpose of this study was to evaluate the effect of hCG treatment on the gonadal response and penile growth in male idiopathic hypogonadotrophic hypogonadism IHH presenting with micropenis. A total of 20 IHH patients who met the criteria for micropenis were included in this study.
Basic laboratory and hormonal indexes including serum testosterone and LH levelspenis length flaccid and stretchedand testicular volume were measured before and 24 weeks after hCG treatment. The patients' mean age was The mean serum testosterone level was significantly increased after hCG treatment baseline, 2, 4, 12, and 24 weeks: 0. Mean penile length also increased significantly 24 weeks after treatment flaccid length: from 3.
Mean testicular volumes increased significantly as well left: from 5. There were no remarkable adverse effects of the hCG treatment. The hCG treatment increased the serum testosterone level, penile length, and testicular volume in IHH patients. Our results suggest that hCG treatment has a beneficial effect on gonadal function and penile growth in patients with IHH presenting with micropenis. Idiopathic hypogonadotrophic hypogonadism IHH is associated with deficient pituitary gonadotropin secretion due to impaired secretion of GnRH from the hypothalamus.
The deficiency may be isolated or may occur in conjunction with other disorders. Normal testosterone levels may be achieved with exogenous testosterone administration.
Alternatively, endogenous testosterone secretion can be stimulated by using hCG. One study reported that the final testicular volume in patients with IHH treated with hCG was substantially greater than that in patients treated with testosterone.
Micropenis refers to an extremely small penis with a stretched penile length of less than 2. The purpose of this study was therefore to determine the effect of hCG therapy on the gonadal response and penile growth in men with IHH who presented with micropenis. A total of 20 male patients with IHH who met the criteria for micropenis were included in this study.
The results were analyzed retrospectively by chart review and were approved by an institutional review board and ethics committee. Patients with cryptorchidism or its absence according to the imaging studies conducted at the initial presentation were excluded.
The hCG stimulation test was performed in all patients to exclude primary testicular insufficiency. Additionally, all men had normal basal thyroid and adrenal function. A pituitary mass lesion or a suprasellar tumor was excluded by skull X-ray and by cranial computed tomography. The diagnosis of IHH was made on the basis of low or normal serum LH and FSH concentrations associated with low serum testosterone, otherwise normal anterior pituitary function, and no demonstrable lesion on a high-resolution CT scan or MRI of the hypothalamic-pituitary area.
Testis volume was assessed by using the Prader orchidometer. Serum testosterone was measured following organic solvent extraction by radioimmunoassay. Basic laboratory and endocrine assessments were performed including serum testosterone, LH, and FSH levels and penis length flaccid and stretched and testicular volume were measured before and after hCG treatment.
The patients were treated by using a standard protocol of 1, IU to 2, IU hCG administrated intramuscularly, 3 times per week, for 8 weeks.Updated on April 5, by Juice.
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HCG is a powerful naturally occurring hormone that is valued by steroid users for the ability it has to help increase, maintain or restore normal testosterone production. Find out all you need to know about what HCG can do and how to use it in my guide below. My HCG guide has been broken down into the following sections:. Human Chorionic Gonadotropin is a hormone naturally found in women and has an important role to play in pregnancy; in fact the hormone is only formed once a woman is pregnant as it is produced after implantation by the placenta and once HCG levels rise enough it is enough to confirm if a woman is pregnant.
HCG does have a medical role for men: to treat low testosterone or hypogonadism. HCG is useful for stimulating an increased production of testosterone in men as well as increasing sperm production, making it a treatment for male infertility as well as alleviating the terrible symptoms suffered by males with low testosterone.
LH can be described as a pituitary analog to HCG because they are hormones produced in different parts of the body luteinizing hormone forms in the pituitary gland but have a similar function. This is where HCG becomes very relevant to men: LH is vital for stimulating natural testosterone production.
This is what makes HCG a popular option for PCT usage in particular, where the recovery of normal testosterone function following anabolic steroid suppression is required. While SERMs and aromatase inhibitors are generally widely accepted as a necessary addition for any steroid user, HCG comes under much more debate with some anabolic steroid users swearing by its use, and others finding that it is not necessary or useful or comes with a greater risk than the other drugs.
In any case, when HCG is used it is rarely used alone but in conjunction with SERMs in post cycle therapy and only at low doses for short periods of time if used during a steroid cycle. Although considered a side effect friendly hormone for most people, HCG comes with one particular risk factor that we need to be concerned about, and this revolves around dependence. For steroid users who make use of HCG while using anabolic steroids the intent is to use this hormone to address the suppression of natural hormones that takes place when you use most types of steroids.
During this time your normal testosterone production and levels will be extremely low or even non-existent and the use of HCG during steroid use can prevent the problem of testicular atrophy but more importantly, taking HCG during a steroid cycle helps prime the body for recovery once your cycle ends. Those men who go overboard with their use of HCG during a steroid cycle, either through lack of knowledge or a false belief that more equals better, can quickly find themself suffering with a low testosterone condition.
Those who know how to use HCG responsibly during a steroid cycle however will reap the benefits and avoid the problem of dependence occurring. HCG on the other hand is a naturally occurring hormone produced in women once they fall pregnant. HCG does not target estrogen in any way, but instead is able to directly help stimulate testosterone in men because it works in a very similar way to luteinizing hormone. HCG is used medically to treat low testosterone and infertility and men, as well as fertility problems in women.
All three categories of substances are therefore available with a prescription.Context and Objective: In men with infertility secondary to gonadotropin deficiency, treatment with relatively high dosages of human chorionic gonadotropin hCG stimulates intratesticular testosterone IT-T biosynthesis and spermatogenesis. Design, Setting, Patients, and Intervention: We induced experimental gonadotropin deficiency in 37 normal men with the GnRH antagonist acyline and randomized them to receive one of four low doses of hCG: 0, 15, 60, or IU sc every other day or 7.
Testicular fluid was obtained by percutaneous aspiration for steroid measurements at baseline and after 10 d of treatment and correlated with contemporaneous serum hormone measurements. Conclusion: Doses of hCG far lower than those used clinically increase IT-T concentrations in a dose-dependent manner in normal men with experimental gonadotropin deficiency.
Assessment of IT-T provides a valuable tool to investigate the hormonal regulation of spermatogenesis in man.Instructions for Injecting Low-Dose hCG - Encompass Fertility Treatment
Intratesticular testosterone IT-T is essential for spermatogenesis. In men with infertility secondary to hypogonadotrophic hypogonadism, injections of human chorionic gonadotropin hCGwhich mimics the activity of LH, stimulates the testicular biosynthesis of testosterone. Treatment with hCG often in combination with injections of FSH leads to spermatogenesis and fertility in approximately two thirds of men 1.
However, the minimum concentration of IT-T necessary for spermatogenesis in man is unknown.
How to use hCG for Men to Boost Testosterone, Fertility & Weight Loss
This may be relevant in male hormonal contraceptive development because spermatogenesis is not consistently suppressed in some men, despite marked suppression of gonadotropins. In these men, persistently elevated IT-T concentrations may allow for ongoing spermatogenesis despite gonadotropin suppression 5678.
A better understanding of the relationship between low concentrations of IT-T and spermatogenesis would be useful to optimize the treatment of male infertility and would inform efforts to develop a male hormonal contraceptive. Understanding the intratesticular steroid environment in man is challenging. Until recently methods for measuring intratesticular hormone concentrations in men required testicular biopsy 91011 ; therefore, prior studies were performed mainly in infertile men requiring testicular biopsy and general anesthesia for the evaluation and treatment of their condition.
More recently the technique of fine-needle tissue aspiration has been used to obtain intratesticular fluid in normal men 51213 This technique can be safely performed in the outpatient setting using local anesthesia without serious adverse effects.
However, although the doses of hCG in our previous work were lower than those used to treat patients with hypogonadotropic hypogonadism, IT-T concentrations were similar to those in untreated normal men In addition, our previous work relied on exogenous testosterone to suppress the hypothalamic-pituitary-gonadal axis, and there was concern that the exogenous testosterone could potentially increase IT-T concentrations.
Therefore, in this study, we experimentally induced low levels of IT-T in normal men using the GnRH antagonist, acyline, and subsequently stimulated testicular testosterone biosynthesis with very low doses of hCG, lower than we used previously. In addition, we included a group of men treated with exogenous testosterone to determine whether treatment with testosterone would affect intratesticular steroid concentrations.
In this way, we sought to ascertain the dose-response relationship between very low doses of LH-like stimulation and IT-T in man.
Healthy men, aged 18—50 yr, were recruited for this study using rosters from prior research studies and newspaper and online advertisements. Informed consent was obtained from all subjects before the screening evaluation.
Exclusion criteria included poor general health; abnormal blood test results; active skin conditions that would prevent the use of testosterone gel; active alcohol or drug abuse; history of testicular or scrotal surgery; infertility; chronic pain syndrome; use of steroids, testosterone, or medications that might affect androgen metabolism including ketoconazole, glucocorticoids; known bleeding disorder; or use of medications that may affect bleeding time such as ongoing aspirin or warfarin use.
All subjects had to agree to use a reliable form of contraception during the study. The study design is illustrated in Fig.NEW ORLEANS — Low-dose human chorionic gonadotropin, or hCGmay preserve spermatogenesis in men with hypogonadism treated with intramuscular or transdermal testosterone replacement therapy, according to a speaker at the Androgen Society annual meeting. The estimated male population in their reproductive years is about 52 million in the United States, with the age of first-time fathers rising, and about 2.
Lipshultz, MD, a professor of urology and chief of the division of male reproductive medicine and surgery at Baylor College of Medicine in Houston, said during a presentation. Intratesticular testosterone — typically 50 to times higher than serum testosterone levels — is a prerequisite for normal sperm production in men; however, exogenous testosterone prescribed to men with hypogonadism suppresses the intratesticular testosterone level, impairing fertility.
Small studies suggest that men treated with testosterone who subsequently developed azoospermia experienced a recovery of spermatogenesis in about 4 months after discontinuing exogenous testosterone, regardless of the testosterone preparation, and initiating intramuscular hCG every other day, Lipshultz said.
However, the studies were single-arm, observational and retrospective in nature, he added.
The findings, Lipshultz said, led researchers to question whether it was possible to prevent sterility in a man with hypogonadism who must use testosterone. Coviello, MD, a reproductive endocrinologist and practicing clinician and researcher at Boston University School of Medicine, and colleagues analyzed data from 29 men with normal reproductive physiology randomly assigned to mg testosterone enanthate weekly in combination with saline placebo or IU, IU or IU hCG every other day for 3 weeks.
The researchers found that intratesticular testosterone increased linearly with increasing hCG dose, demonstrating that a relatively low dose of hCG maintains intratesticular testosterone within the normal range in healthy men with gonadotropin suppression, Lipshultz said.
A small, prospective study indicated that may be true, Lipshultz said. Men underwent routine semen analyses throughout the study mean follow-up, 4. In an expanded study assessing a larger population of 26 patients, results were similar, Lipshultz said. Low-dose hCG appeared to maintain sperm quality in men with hypogonadism using testosterone replacement therapy.
To maintain fertility in men with hypogonadism prescribed testosterone, Lipshultz said, clinicians should first insist on a semen analysis before beginning testosterone treatment.
If the man desires a future pregnancy, the clinician should prescribe hCG concurrent with testosterone therapy, typically at U subcutaneous three times per week or 1, U once weekly if the patient wishes only to prevent testicular atrophy.
The patient should cycle off of testosterone twice yearly, at a rate of 3, U three times per week for 4 weeks, adding 25 mg daily clomiphene therapy during that period, Lipshultz said.
However, for men desiring a pregnancy, 3, U hCG three times per week should be prescribed in addition to clomiphene therapy. Lipshultz LI. Strategies for fertility preservation in men on testosterone therapy.
Disclosure: Endocrine Today could not confirm relevant financial disclosures at the time of publication. Tell us what you think about Healio. Login Register My Saved. Meeting News. The Androgen Society. Please provide your email address to receive an email when new articles are posted on this topic.
Receive an email when new articles are posted on this topic. You have already added this topic to your email alerts. Click here to manage your alerts. Larry I. Coviello AD, et al. J Clin Endocrinol Metab. Follow Healio. Sign Up for Email Get the latest news and education delivered to your inbox Email address. Account Information.Also known as low testosterone, Low-T is one of the reasons men are considering testosterone replacement therapy.
What you might not realize is that testosterone alone may not be the best way to increase testosterone levels. Men need testosterone for many reasons:. Declining testosterone is a normal part of getting older, but it could also be caused by a condition like hypogonadism.
A problem with the testicles could be to blame, or hypogonadism could be the result of a problem with the pituitary gland.
The pituitary gland is a small organ that tells the testicles to produce testosterone. Some men choose to begin TRT to treat hypogonadism, while others choose TRT to reverse or slow the natural decrease in testosterone that comes with age. Since your testicles will produce less and less testosterone, they may become smaller.
HCG is a hormone that tells the pituitary gland to produce more testosterone. By encouraging natural testosterone production, HCG helps in two ways:. In addition to these two benefits, HCG also helps keep communication flowing between a set of extremely important glands in the body — the hypothalamus, the pituitary gland, and the adrenal gland — known as the HPA axis.
When the HPA axis is open and flowing smoothly, hormones like testosterone are being produced naturally, and adrenal function is improved. Good adrenal function translates to a greater sense of well-being, more energy, and a higher libido.
Our HCG mini-tabs are sugar-free and melt completely under the tongue. For an extra boost of energy, our tabs include micrograms of hydroxocobalamin Vitamin B Our tabs remain stable at room temperature and have been potency-tested for quality. Depending on your personal goals for testosterone therapy, HCG may be the perfect addition to your treatment. Show all. What Is Testosterone? But TRT is not without potential side effects. Shrinking testicles can also lead to fertility problems.
By encouraging natural testosterone production, HCG helps in two ways: encourages natural testosterone production in addition to TRT helps prevent the side effects of testicle shrinkage and infertility that may occur as a result of TRT In addition to these two benefits, HCG also helps keep communication flowing between a set of extremely important glands in the body — the hypothalamus, the pituitary gland, and the adrenal gland — known as the HPA axis.
Ready to add HCG to your testosterone regimen? Click here to get a quote! Related posts.In this post you will find the answers to these questions and more, including how hCG can be effective in men, how it can help increase testosterone, help with weight loss and more :. It's really just a hormone, but we often associate it with the hCG diet and tend to only think about it in those terms. But hCG can actually be used in both men and women for many other purposes, especially as a part of hormone therapy.
These benefits are thought to be mediated through the effects that hCG has on certain cellular receptors. At the molecular level, hCG looks similar to another hormone known as LH secreted by the pituitary gland 3. What this means is that hCG can lock onto and stimulate LH receptors, especially in the testicles. Stimulation of LH receptors then goes on to help produce adequate sperm and testosterone production.
We can take advantage of this physiology by using hCG in certain situations to naturally improve HPT hypothalamic-pituitary-testicular function. And this is important because there are very few actual "testosterone boosters" available to men.
The only way to increase testosterone is to reverse conditions that prematurely lower it such as insulin resistancetake exogenous testosterone such as TRT or stimulate natural production from the testicles such as hCG. I've previously written about testosterone boosters and why most of them are simply hype and marketingbut hCG is the real deal.
This includes men taking existing testosterone and men who simply suffer from low testosterone from other causes.
The answer is probably not because there are better, more effective ways, to treat low testosterone. We know that there is a natural, and inevitable, decline in testosterone production and testicular function in men which occurs with age. At some point, usually around 50 years of age, men go through what is known as andropausewhich results in very low levels of testosterone.
Premature decline in testosterone is also becoming more and more common among younger men, especially in the 20's and 30's.
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This decline in testosterone may result in fatigue, weight gain, an increased risk of cardiovascular disease, depression and erectile dysfunction 4. While it may be tempting to look to testosterone boosters, such as hCG or other marketed supplements, the best approach is to look at combination TRT therapy.
The symptoms of low T can almost always be abated with the use of exogenous TRT testosterone replacement therapyespecially when combined with hCG. In fact, I believe that hCG is a necessary component of TRT and should be used in most men who consider using testosterone. When men use exogenous testosterone meaning testosterone from an outside source the normal response is for the body to shut down its own natural production of testosterone.
The hypothalamic-pituitary-testicular system is very sensitive to outside testosterone and it responds by reducing its own natural production of testosterone and by reducing both FSH and LH 5. These hormones, FSH and LH secreted from the pituitaryare important, though, because of their role in maintaining testicular size.
In response to intramuscular testosterone but really this can be expanded to include any exogenous source of testosterone both FSH and LH will drop to very low suppressive ranges within days.
This can largely be mitigated with the use of hCG which acts directly on the testis as an LH agonist. The benefit to using hCG in this way is that men will NOT experience testicular atrophy shrinking of the testicles in response to testosterone administration.
Men who use TRT may complain of shrinkage of the testicles over time as well as testicular pain, both of which are felt to stem from reductions in LH. In addition, the impact that hCG has on LH receptors in the testis will result in a minor increase in natural testosterone production thus increasing testosterone levels. This benefit occurs through manipulation of the intratesticular androgenic environment and may be why hCG can sometimes to be used to improve fertility in some men 6.
No doubt, by now, that you've heard about the hCG diet and how it can help with weight loss. It's worth pointing out that hCG is an effective tool for weight loss, but it should NOT be used in the "traditional way".
I've outlined exactly how to use hCG as part of a weight loss program and as a tool for hormone balance in this post. What you may not realize is that most men who use the hCG diet for weight loss do tend to experience more dramatic weight loss when compared to women.
Testosterone is probably one of the most effective tools medications or otherwise at helping MEN and sometimes women achieve their weight loss goals. Testosterone improves body composition by increasing lean muscle mass, helping improve metabolism of adipose tissue and by improving metabolic function.